Folkman J, Shing Y: Angiogenesis. J Biol Chem 267:10931–10934, 1992.
Klagsbrun M, D'Amore PA: Regulators of angiogenesis. Annu Rev Physiol 53:217–239, 1991.
Folkman J: What is the evidence that tumors are angiogenesis-dependent? J Natl Cancer Inst 82:4–6, 1991.
Weidner N, Semple P, Welch W, Folkman J: Tumor angiogenesis and metastasis. Correlation in invasive breast carcinoma. New Engl J Med 324:1–6, 1991.
Vartanian RK, Weidner N: Correlation of intramural endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation. Am J Pathol 144:1188–1194, 1994.
Horak ER, Leek R, Klenk N, Lejeune S, Smith K, Stuart M, Greenall M, Harris AL: Quantitative angiogenesis assessed by anti-PECAM antibodies: correlation with node metastasis and survival in breast cancer. Lancet 340:1120–1124, 1992.
Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G: Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 84:1875–1888, 1992.
Chodak GW, Haudenschild C, Gittes RF, Folkman J: Angiogenic activity as a marker of neoplastic and preneoplastic lesions of the human bladder. Ann Surg 192:762–771, 1980.
Wakui S, Furusato M, Sasaki H, Akiyama A, Kinoshito I, Asano K, Tokuda T, Aizawa S, Ushigome S: Tumor angiogenesis in prostatic carcinoma with and without bone metastasis: a morphometric study. J Pathol 168:257–262, 1992.
Bigler SA, Deering RE, Brawer MK: Comparison of microscopic vascularity in benign and malignant prostatic tissue. Human Pathol 24:220–226, 1993.
Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA: Relation of neovascularization to metastasis of non-small cell lung carcinoma. Lancet 340:145–146, 1992.
Sillman F, Boyce J, Fruchter R: The significance of atypical vessels and neovascularization in cervical neoplasias. Am J Obstet Gynecol 139:154–157, 1981.
Srivastava A, Laidler P, Davies R, Horgan K, Hughes LE: The prognostic significance of tumor vascularity in intermediate-thickness (0.76–4.0 mm thick) skin melanoma. Am J Pathol 133:419–423, 1988.
Smith-McCune KS, Weidner N: Demonstration and characterization of the angiogenic properties of cervical dysplasia. Cancer Res 54:804–808, 1994.
Ferrara N, Henzel WJ: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161:851–859, 1989.
Ferrara N, Houck K, Jakeman L, Leung DW: Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 13:18–32, 1992.
Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, Feder J: Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84:1470–1478, 1989.
Ploüet J, Schilling J, Gospodarowicz D: Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT20 cells. EMBO J 8:3801–3807, 1989.
Leung DW, Cachianes G, Kuang W-J, Goeddel DV, Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306–1309, 1989.
Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT: Vascular permeability factor, an endothelial cell mitogen related to platelet derived growth factor. Science 246:1309–1312, 1989.
Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW: The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5:1806–1814, 1991.
Tisher E, Mitchell R, Hartmann T, Silva M, Gospodarowicz D, Fiddes J, Abraham J: The human gene for vascular endothelial growth factor. J Biol Chem 266:11947–11954, 1991.
Breier G, Albrecht U, Sterrer S, Risau W: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 114:521–532, 1992.
Jakeman LB, Armanini M, Phillips HS, Ferrara N: Developmental expression of binding sites and mRNA for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology 133:848–859, 1993.
Phillips HS, Hains J, Leung DW, Ferrara N: Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology 127:965–968, 1990.
Ravindranath N, Little-Ihrig L, Phillips HS, Ferrara N, Zeleznick AJ: Vascular endothelial growth factor mRNA expression in the primate ovary. Endocrinology 131:254–260, 1992.
Shweiki D, Itin A, Neufeld G, Gitay-Goren H, Keshet E: Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J Clin Invest 91:2235–2243, 1993.
Banai S, Jaktlish MT, Shou M, Lazarous DF, Scheinowitz M, Biro S, Epstein S, Unger E: Angiogenicinduced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 89:2183–2189, 1994.
Takeshita S, Zhung L, Brogi E, Kearney M, Pu L-Q, Bunting S, Ferrara N, Symes JF, Isner JM: Therapeutic angiogenesis: A single intra-arterial bolus of vascular endothelial growth factor augments collateral vessel formation in a rabbit ischemic hindlimb model. J Clin Invest 93:662–670, 1994.
Takeshita S, Zheng LP, Cheng D, Riessen R, Weir L, Symes JF, Ferrara N, Isner JM: Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia. Proc Natl Acad Sci USA, in press.
Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N: Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362:841–844, 1993.
Ferrara N: Vascular endothelial growth factor. Trends Cardiovasc Med 3:244–250, 1993.
Aiello LP, Avery R, Arrigg R, Keyt B, Jampel H, Shah S, Pasquale L, Thieme H, Iwamoto M, Park JE, Nguyen H, Aiello LM, Ferrara N, King GL: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331:1480–1487, 1994.
Adamis AP, Shima DT, Tolentino M, Gragoudas E, Ferrara N, Folkman J, D'Amore PA, Miller JW: Inhibition of VEGF prevents ocular neovascularization in a primate model. Submitted.
Pepper MS, Ferrara N, Orci L, Montesano R: Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 189:824–831, 1992.
Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K: Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 269:6271–6274, 1994.
Dvorak HF: Tumors: wounds that do not heal. Similarity between tumor stroma generation and wound healing. N Engl J Med 315:1650–1658, 1986.
Pepper MS, Ferrara N, Orci L, Montesano R: Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor type 1 in microvascular endothelial cells. Biochem Biophys Res Commun 181:902–908, 1991.
Unemori E, Ferrara N, Bauer EA, Amento EP: Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153:557–562, 1992.
Gross J, Nagai Y: Specific degradation of the collagen molecule by tadpole collagenolytic enzyme. Proc Natl Acad Sci USA 54:1197–1204, 1965.
Pepper MS, Montesano R: Proteolytic balance and capillary morphogenesis. Cell Diff Dev 32:319–331, 1990.
Ku DD, Zaleski JK, Liu S, Brock T: Vascular endothelial growth factor induces EDRF-dependent relaxation of coronary arteries. Am J Physiol 265: H586–592, 1993.
Park JE, Chen H, Winer J, Houck K, Ferrara N: Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 269:25646–25654, 1994.
Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG: Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 88: 9267–9271, 1991.
Hauser S, Weich HA: A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. Growth Factors 9:259–268, 1993.
Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843–845, 1992.
Goldberg MA, Schneider TJ: Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 269:4355–4361, 1994.
Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N: Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267:26031–26037, 1992.
Park JE, Keller G-A, Ferrara N: The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of ECM-bound VEGF. Mol Biol Cell 4:1317–1326, 1993.
Mignatti P, Tsuboi R, Robbins E, Rifkin DB: In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J Cell Biol 108:671–682, 1989.
Rifkin DB, Moscatelli D, Bizik J, Quarto N, Blei F, Dennis P, Flaumenhaft R, Mignatti P: Growth factor control of extracellular proteolysis. Cell Differ Dev 32:313–318, 1990.
Sreenath T, Matrisian LM, Stetler-Stevenson W, Gattoni-Celli S, Pozzatti RO: Expression of matrix metalloproteinases in transformed rat cell lines of high and low metastatic potential. Cancer Res 52:4942–4947, 1992.
Vaisman N, Gospodarowicz D, Neufeld G: Characterization of the receptors for vascular endothelial growth factor. J Biol Chem 265:19461–19469, 1990.
Ploüet J, Moukadiri HJ: Characterization of the receptors to vasculotropin on bovine adrenal cortexderived capillary endothelial cells. J Biol Chem 265:22071–22075, 1990.
Shen H, Clauss M, Ryan J, Schmidt AM, Tijburg P, Borden L, Connolly DT, Stern D, Kao J: Characterization of vascular permeability factor/vascular endothelial growth factor receptors in mononuclear phagocytes. Blood 81:2767–2773, 1993.
Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N: Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 89:244–253, 1992.
deVries C, Escobedo JA, Ueno H, Houck KA, Ferrara N, Williams LT: The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989–991, 1992.
Terman BI, Vermazen MD, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem Biophys Res Commun 34:1578–1586, 1992.
Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A: High affinity binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835–846, 1993.
Quinn T, Peters KG, deVries C, Ferrara N, Williams LT: Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 90: 7533–7537, 1993.
Shibuya M, Yamaguchi S, Yamane A, Ikada T, Tojo T, Matsushime H, Sato M: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to thefms family. Oncogene 8:519–527, 1990.
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB: Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6:519–524, 1991.
Matthews W, Jordan CT, Gavin M, Jenkins NA, Copeland NG, Lemischka IR: A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci USA 88:9026–9030, 1991.
Kendell RL, Thomas KA: Inhibition of vascular endothelial growth factor by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 90:10705–10709, 1993.
Peters KG, deVries C, Williams LT: Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 90:8915–8919, 1993.
Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin C-H: Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988–26995, 1994.
Senger D, Perruzzi CA, Feder J, Dvorak HF: A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 46:5269–5275, 1986.
Rosenthal R, Megyesi JF, Henzel WJ, Ferrara N, Folkman J: Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor. Growth Factors 4:53–59, 1990.
Takahashi A, Sasaki H, Kim SJ, Tobisu K, Kakizoe T, Tsukamoto T, Kumamoto Y, Sugimura T, Tarada M: Markedly increased amounts of messenger RNA for VEGF and PlGF in renal cell carcinoma associated with angiogenesis. Cancer Res 54:4233–4237, 1994.
Olson TA, Mohanraj D, Carson LF, Ramakrishnan S: Vascular permeability factor gene expression in normal and neoplastic human ovaries. Cancer Res 54:276–280, 1994.
Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, Dvorak HF: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res 53: 4727–4735, 1993.
Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth is a potential tumour angiogenesis factor in vivo. Nature 359:845–847, 1992.
Phillips HS, Armanini M, Stavrou D, Ferrara N, Westphal M: Intense focal expression of vascular endothelial growth factor mRNA in human intracranial neoplasms: Association with regions of necrosis. Int J Oncol 2:913–919, 1993.
Berkman RA, Merrill MJ, Reinhold WC, Monacci WT, Saxena A, Clark WC, Robertson JT, Ali IU, Oldfield EH: Expression of the vascular permeability/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 91: 153–159, 1993.
Toi M, Hoshima S, Takayanagi T, Tominaga T: Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85:1045–1049, 1994.
Ferrara N, Winer J, Burton T, Rowland A, Siegel M, Phillips HS, Terrell T, Keller G-A, Levinson AD: Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J Clin Invest 91:160–170, 1993.
Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A: Glioblastoma growth is inhibited in vivo by a negative dominant Flk-1 mutant. Nature 367:576–579, 1994.
Warren RS, Yuan H, Matli MR, Gillett NA, Ferrara N: Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 95:1789–1797, 1995
Altman RJ, Mesiano S, Ferrara N, Jaffe RB: Vascular endothelial growth factor is essential for human ovarian carcinoma growth in vivo. Submitted.
Patz A: Studies on retinal neovascularization. Invest Ophthalmol Vis Sci 19:1133–1138, 1980.
Michaelson IC: The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders. Trans Ophthalmol Soc UK 68:137–180, 1948.
Meyer-Schwickerath R, Pfeiffer A, Blum WF, Freyberger H, Klein M, Losche C, Rollman R, Schatz H: Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3 increase in neovascular disease. J Clin Invest 92:2620–2625, 1993.
Hannehan A, deJuan E, Lutti GA, Fox GM, Schiffer S, Hjelmeland LM: Altered distribution of basic fibroblast growth factor in diabetic retinopathy. Arch Ophthalm 109:1005–1011, 1991.
Adamis AP, Miller JW, Bernal M-T, D'Amico D, Folkman J, Yeo T-K, Yeo K-T: Increased vascular endothelial growth factor in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 118:445–450, 1994.
Miller JW, Adamis AP, Shima DT, d'Amore PA, Moulton RS, O'Reilly MS, Folkman J, Dvorak HF, Brown LF, Berse B, Yeo T-K, Yeo K-T. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular neovascularization in a primate model. Am J Pathol 145:574–584, 1994.
Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong W-L, Pope RM, Ferrara N: Vascular endothelial growth factor: a cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 152:4149–4156, 1994.
Fava RA, Olsen NJ, Spencer-Green G, Yeo T-K, Yeo K-T, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF: Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid arthritis. J Exp Med 180:340–346, 1994.
Fassbender HJ, Simling-Annefeld M: The potential aggressiveness of synovial tissue in rheumatoid arthritis. J Pathol 139:399–406, 1983.
Hamilton J: Hypothesis: In vitro evidence for the invasive and tumor-like properties of the rheumatoid pannus. J Rheumatol 10:845–851, 1976.
Thompson RW, D'Amore PA: Recruitment of growth and collateral circulation.In: Zelenock GB, D'Alecy LG, Fantone JC III, Shlafer M, Stanley JC (eds) Clinical Ischemic Syndromes: Mechanisms and Consequences of Tissue Injury. Mosby, St. Louis, 1990, pp 117–134.
Graor RA, Gray BH: Interventional treatment of peripheral vascular disease.In: Young JR, Graor RA, Olin JW, Bartholomew JR (eds) Peripheral Vascular Diseases. Mosby, St. Louis, 1991, pp 111–133.