Cancer and Metastasis Reviews

, Volume 12, Issue 3, pp 303–324

Vascular permeability factor (VPF, VEGF) in tumor biology

Authors

  • Donald R. Senger
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Livingston Van De Water
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Lawrence F. Brown
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Janice A. Nagy
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Kiang-Teck Yeo
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Tet-Kin Yeo
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Brygida Berse
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Robert W. Jackman
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Ann M. Dvorak
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
  • Harold F. Dvorak
    • Departments of PathologyBeth Israel Hospital and Harvard Medical School
Article

DOI: 10.1007/BF00665960

Cite this article as:
Senger, D.R., Van De Water, L., Brown, L.F. et al. Cancer Metast Rev (1993) 12: 303. doi:10.1007/BF00665960

Summary

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a multifunctional cytokine expressed and secreted at high levels by many tumor cells of animal and human origin. As secreted by tumor cells, VPF/VEGF is a 34–42 kDa heparin-binding, dimeric, disulfide-bonded glycoprotein that acts directly on endothelial cells (EC) by way of specific receptors to activate phospholipase C and induce [Ca2+]i transients. Two high affinity VPF/VEGF receptors, both tyrosine kinases, have thus far been described. VPF/VEGF is likely to have a number of important roles in tumor biology related, but not limited to, the process of tumor angiogenesis. As a potent permeability factor, VPF/VEGF promotes extravasation of plasma fibrinogen, leading to fibrin deposition which alters the tumor extracellular matrix. This matrix promotes the ingrowth of macrophages, fibroblasts, and endothelial cells. Moreover, VPF/VEGF is a selective endothelial cell (EC) growth factorin vitro, and it presumably stimulates EC proliferationin vivo. Furthermore, VPF/VEGF has been found in animal and human tumor effusions by immunoassay and by functional assays and very likely accounts for the induction of malignant ascites. In addition to its role in tumors, VPF/VEGF has recently been found to have a role in wound healing and its expression by activated macrophages suggests that it probably also participates in certain types of chronic inflammation. VPF/VEGF is expressed in normal development and in certain normal adult organs, notably kidney, heart, adrenal gland and lung. Its functions in normal adult tissues are under investigation.

Key words

vascular permeability factor vascular endothelial growth factor endothelial cells

Copyright information

© Kluwer Academic Publishers 1993