Current Genetics

, Volume 10, Issue 2, pp 87–93

Functional nuclear suppressor of mitochondrialoxi2 mutations in yeast

  • Anna Kruszewska
  • Barbara Szcześniak
Original Articles

DOI: 10.1007/BF00636472

Cite this article as:
Kruszewska, A. & Szcześniak, B. Curr Genet (1985) 10: 87. doi:10.1007/BF00636472


A semidominant nuclear suppressor, callednam6, ofoxi2-V276 mitochondrial mutation has been isolated and characterized. The nuclear character ofnam6 was proved by its retention inrho° strains, lack of mitotic segregation in diploids and meiotic 2:2 segregation in tetrads. The specificity ofnam6 was tested on 315mit mutations of four mitochondrial genes (oxi1, oxi2, oxi3, andcob-box). It suppresses clearly only three mutations in theoxi2 gene, restoring partially or completely cytochrome aa3 formation. The results suggest a functional character of the suppression.

Key words

YeastMitochondriaoxi2 mutationsFunctional suppressors

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Anna Kruszewska
    • 1
  • Barbara Szcześniak
    • 1
  1. 1.Institute of Biochemistry and Biophysics Polish Academy of SciencesWarsawPoland