Journal of Cancer Research and Clinical Oncology

, Volume 106, Supplement 1, pp 21–24

Morphological grades of regression in osteosarcoma after polychemotherapy — Study COSS 80


  • M. Salzer-Kuntschik
    • The Vienna Bone Tumor Registry at the Pathologic Institute of the University of Vienna
  • G. Delling
    • The Pathologic Institute of the University of Hamburg
  • G. Beron
    • The Department of Blood Coagulation Research and Oncology at the Pediatric Clinic of the University of Hamburg
  • R. Sigmund
    • The Orthopedic Clinic of the University of Vienna
Symposium of the Cooperative Osteosarcoma Study Group — COSS 80 A Combined Diagnostic and Therapeutic Approach to Osteosarcoma Treatment May 7, 1982 in Viena

DOI: 10.1007/BF00625047

Cite this article as:
Salzer-Kuntschik, M., Delling, G., Beron, G. et al. J Cancer Res Clin Oncol (1983) 106: 21. doi:10.1007/BF00625047


The histologic grade of regression of 50 osteosarcomas after polychemotherapy — according to the protocol study, COSS 80 — was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- and CPL-treated patients could be found. Tumors under 10 cm in length responded better to chemotherapy than those of greater length and there was a good correlation between the clinical estimation of tumor regression and progression and the histologic grade of regression.

Key words

OsteosarcomaChemotherapyHistologic grades of regression

Copyright information

© Springer-Verlag 1983