Virchows Archiv A

, Volume 398, Issue 2, pp 221–228

Immunohistochemical analysis of thyroglobulin and keratin in benign and malignant thyroid tumours

  • W. Permanetter
  • W. B. J. Nathrath
  • U. Löhrs
Article

DOI: 10.1007/BF00618871

Cite this article as:
Permanetter, W., Nathrath, W.B.J. & Löhrs, U. Vichows Archiv A Pathol Anat (1982) 398: 221. doi:10.1007/BF00618871

Summary

56 thyroid gland tumours and non neoplastic alterations were studied for keratin and thyroglobulin staining, using the indirect immunoperoxidase method on serial formalin fixed paraffin embedded sections. Papillary carcinomas showed a strong reaction with anti-keratin serum but a weak reaction with anti-thyroglobulin serum. Follicular adenomas and carcinomas showed virtually no reaction for keratin but a strong reaction for thyroglobulin. Undifferentiated and medullary carcinomas did not react with either antiserum, except for single cells in two undifferentiated carcinomas which reacted with anti-keratin serum. In nodular goiters, hyperplastic follicles showed little or no reaction with anti-keratin serum and strong reaction with anti-thyroglobulin serum.

It is suggested that this virtually type-specific staining for keratin or thyroglobulin may be related to different degrees of cellular differentiation and organelle content in the tumour cells.

Key words

Thyroid tumour Immunohistochemistry Keratin Thyroglobulin Differential diagnosis 

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • W. Permanetter
    • 1
  • W. B. J. Nathrath
    • 1
  • U. Löhrs
    • 1
  1. 1.Pathologisches Institut der Universität MünchenMünchen 2Germany