European Journal of Clinical Pharmacology

, Volume 34, Issue 2, pp 145–150

Effect of prednisolone and ketotifen onβ2-adrenoceptors in asthmatic patients receivingβ2-bronchodilators

Authors

  • O. E. Brodde
    • Biochemical Research Laboratory, Medizinische Klinik und Poliklinik, Division of Renal and Hypertensive DiseasesUniversity of Essen
  • U. Howe
    • Biochemical Research Laboratory, Medizinische Klinik und Poliklinik, Division of Renal and Hypertensive DiseasesUniversity of Essen
  • S. Egerszegi
    • Ruhrlandklinik Essen
  • N. Konietzko
    • Ruhrlandklinik Essen
  • M. C. Michel
    • Biochemical Research Laboratory, Medizinische Klinik und Poliklinik, Division of Renal and Hypertensive DiseasesUniversity of Essen
Originals

DOI: 10.1007/BF00614551

Cite this article as:
Brodde, O.E., Howe, U., Egerszegi, S. et al. Eur J Clin Pharmacol (1988) 34: 145. doi:10.1007/BF00614551

Summary

In 13 patients with bronchial asthma, who were onβ2-adrenergic bronchodilator therapy, the effects of prednisolone and ketotifen on lymphocyteβ2-adrenoceptor density and -responsiveness were investigated. The mean lymphocyteβ2-adrenoceptor density and -responsiveness was significantly lower than in healthy controls, presumably due to the long-termβ2-adrenergic bronchodilator treatment. Both prednisolone 100 mg i.v. and ketotifen 1 mg b.d.p.o. for 6 days rapidly improved lymphocyteβ2-adrenoceptor function. 16 h after prednisolone and about 6 days after the first dose of ketotifen lymphocyteβ2-adrenoceptor density and-responsiveness had risen to values within the range in normal volunteers.

The improvement of lymphocyteβ2-adrenoceptor function was accompanied by a significant increase in peak expiratory flow rate before and after inhalation of salbutamol.

It is concluded that prednisolone and ketotifen may act beneficially on the recovery ofβ2-adrenoceptor responsiveness toβ2-adrenergic bronchodilators in tolerant asthmatic patients.

Key words

asthmaketotifenprednisolonelymphocyte beta2-adrenoceptorsbeta-adrenoceptor desensitizationtachyphylaxissalbutamolterbutalinetheophylline

Copyright information

© Springer-Verlag 1988