, Volume 34, Issue 2, pp 145-150

Effect of prednisolone and ketotifen onβ 2-adrenoceptors in asthmatic patients receivingβ 2-bronchodilators

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Summary

In 13 patients with bronchial asthma, who were onβ 2-adrenergic bronchodilator therapy, the effects of prednisolone and ketotifen on lymphocyteβ 2-adrenoceptor density and -responsiveness were investigated. The mean lymphocyteβ 2-adrenoceptor density and -responsiveness was significantly lower than in healthy controls, presumably due to the long-termβ 2-adrenergic bronchodilator treatment. Both prednisolone 100 mg i.v. and ketotifen 1 mg b.d.p.o. for 6 days rapidly improved lymphocyteβ 2-adrenoceptor function. 16 h after prednisolone and about 6 days after the first dose of ketotifen lymphocyteβ 2-adrenoceptor density and-responsiveness had risen to values within the range in normal volunteers.

The improvement of lymphocyteβ 2-adrenoceptor function was accompanied by a significant increase in peak expiratory flow rate before and after inhalation of salbutamol.

It is concluded that prednisolone and ketotifen may act beneficially on the recovery ofβ 2-adrenoceptor responsiveness toβ 2-adrenergic bronchodilators in tolerant asthmatic patients.