European Journal of Clinical Pharmacology

, Volume 30, Issue 1, pp 13-16

First online:

Comparative study of the respiratory effects of two beta1-selective blocking agents atenolol and bevantolol in asthmatic patients

  • F. Philip-JoetAffiliated withService de Pneumologie Allergologie, CHU Nord
  • , A. SaadjianAffiliated withService de Pneumologie Allergologie, CHU Nord
  • , B. BruguerolleAffiliated withService de Pneumologie Allergologie, CHU Nord
  • , A. ArnaudAffiliated withService de Pneumologie Allergologie, CHU Nord

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Seven asthmatic patients were given a single placebo tablet in a first test session and then in two subsequent double blind sessions they randomly received 400 mg bevantolol or 100 mg atenolol, with at least 2 days between each of the sessions. Neither beta-blocker had any significant effect on FVC as compared to the placebo. FEV 1, however, was significantly lower 2 and 3 h after atenolol or bevantolol; there was no significant difference between the effects of the two drugs on FEV 1. Peak expiratory flow rate was reduced by bevantolol but not by atenolol, the difference reaching significance after 3 h. Fenoterol inhalation at the end of each test session always enhanced pulmonary performance, but to a lesser extent after bevantolol than after placebo or atenolol. A slower heart rate was recorded 2, 3, and 4 h after bevantolol and 3 and 4 h after atenolol; the mean 2-h value was significantly lower with atenolol than with bevantolol. No patient suffered any adverse effect. Bevantolol may be slightly less selective than atenolol.

Key words

asthma bevantolol atenolol beta-blockers respiratory effect beta-selectivity