European Journal of Clinical Pharmacology

, Volume 12, Issue 3, pp 201–204

The effect of diphenhydramine alone and in combination with ethanol on histamine skin response and mental performance

  • Rosalind Baugh
  • R. T. Calvert

DOI: 10.1007/BF00609861

Cite this article as:
Baugh, R. & Calvert, R.T. Eur J Clin Pharmacol (1977) 12: 201. doi:10.1007/BF00609861


The effects of diphenhydramine and diphenhydramine plus ethanol on response to intradermal histamine and on mental performance were assessed in twelve male volunteers. A significant impairment of histamine skin response was found with diphenhydramine. This response was unaffected by ethanol. Ethanol improved performance with a tracking test compared with diphenhydramine alone, the effect was not potentiated by the combination. None of the treatments had a significant effect on a digit symbol substitution test. Co-administration of ethanol and diphenhydramine caused greater impairment of performance in a serial seven subtraction test than diphenhydramine alone. There was no correlation between central and peripheral effects of the antihistamine.

Key words


Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Rosalind Baugh
    • 1
  • R. T. Calvert
    • 1
  1. 1.The Pharmacy DepartmentUniversity of ManchesterManchesterU.K.