European Journal of Clinical Pharmacology

, Volume 22, Issue 6, pp 553–558

Morphine glucuronidation in human fetal and adult liver

  • G. M. Pacifici
  • J. Säwe
  • L. Kager
  • A. Rane
Originals

DOI: 10.1007/BF00609630

Cite this article as:
Pacifici, G.M., Säwe, J., Kager, L. et al. Eur J Clin Pharmacol (1982) 22: 553. doi:10.1007/BF00609630

Summary

The glucuronyltransferase activity towards morphine was measured in microsomes isolated from liver specimens obtained from human fetuses and cancer patients. All the fetal livers investigated had measurable UDP-glucuronyltransferase activity towards morphine. There was no correlation between the gestational age (15 to 27 weeks) and the glucuronidation rate. The mean value of the enzymatic activities was higher in fetal livers obtained by hysterotomy (0.20 nmoles×min−1×mg−1) than in livers obtained after induced abortion (0.11 nmoles×min−1×mg−1). The average rate of glucuronidation in microsomes from adult liver (mean 1.15 nmoles×mint-1×mg−1) was 6 to 10 times higher than in the fetal liver microsomes. Together with previous investigations on human adult and fetal liver glucuronidation, the present results support the theory of heterogeneity of human UDP-glucuronyltransferase.

Key words

glucuronidation morphine UDP-glucuronyltransferase adult liver fetal liver enzyme heterogeneity 

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • G. M. Pacifici
    • 1
  • J. Säwe
    • 1
  • L. Kager
    • 1
  • A. Rane
    • 1
  1. 1.Departments of Clinical Pharmacology and Surgery, Karolinska InstituteHuddinge HospitalHuddingeSweden