Originals

European Journal of Clinical Pharmacology

, Volume 30, Issue 6, pp 705-708

Pharmacokinetics of albendazole in man

  • S. E. MarrinerAffiliated withDepartment of Veterinary Pharmacology, University of Glasgow Veterinary School
  • , D. L. MorrisAffiliated withThe General Hospital
  • , B. DicksonAffiliated withOverseas Medical Division, Smith, Kline and French Laboratories
  • , J. A. BoganAffiliated withDepartment of Veterinary Pharmacology, University of Glasgow Veterinary School

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

The pharmacokinetics of albendazole were investigated in healthy volunteers and in patients receiving albendazole for treatment of hydatid disease. Unchanged albendazole was below detectable limits in plasma, urine, bile and cyst fluid. The major metabolite present in all fluids was the sulfoxide. Maximum concentrations of albendazole sulfoxide in plasma were very variable, probably due to variable absorption of albendazole.

Key words

albendazole hydatid disease pharmacokinetics man