European Journal of Clinical Pharmacology

, Volume 11, Issue 4, pp 311–315

Cerebrospinal fluid amine metabolites after combined amitriptyline-triiodothyronine treatment of depressed women

  • C. M. Banki

DOI: 10.1007/BF00607682

Cite this article as:
Banki, C.M. Eur J Clin Pharmacol (1977) 11: 311. doi:10.1007/BF00607682


Levels of 5-hydroxyindoleacetic acid and homovanillic acid were measured in cerebrospinal fluid from 33 depressed women with no clinical response to amitriptyline, before and after combination treatment with triiodothyronine. Although the latter showed significant clinical improvement, changes in CSF amine metabolites did not differ significantly from a control group of 16 therapy-resistant depressed women receiving higher doses of amitriptyline. Possible explanations for the mechanism of action of triiodothyronine are discussed.

Key words

Depression triiodothyronine CSF 5-HIAA CSF HVA trimipramine amitriptyline 

Abbreviations used


5-hydroxyindoleacetic acid


homovanillic acid


cerebrospinal fluid



Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • C. M. Banki
    • 1
  1. 1.Department of PsychiatryCounty Neuropsychiatric InstituteNagykálloHungary

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