Originals

European Journal of Clinical Pharmacology

, Volume 20, Issue 2, pp 123-125

Excretion of paracetamol in human breast milk

  • P. -O. BitzénAffiliated withDepartment of Community Care SciencesDepartment of Clinical Pharmacology, Malmö General Hospital, University of LundMedical Department and Research Laboratories, Astra Läkemedel AB
  • , B. GustafssonAffiliated withDepartment of Community Care SciencesDepartment of Clinical Pharmacology, Malmö General Hospital, University of LundMedical Department and Research Laboratories, Astra Läkemedel AB
  • , K. G. JostellAffiliated withDepartment of Community Care SciencesDepartment of Clinical Pharmacology, Malmö General Hospital, University of LundMedical Department and Research Laboratories, Astra Läkemedel AB
  • , A. MelanderAffiliated withDepartment of Community Care SciencesDepartment of Clinical Pharmacology, Malmö General Hospital, University of LundMedical Department and Research Laboratories, Astra Läkemedel AB
  • , E. Wåhlin-BollAffiliated withDepartment of Community Care SciencesDepartment of Clinical Pharmacology, Malmö General Hospital, University of LundMedical Department and Research Laboratories, Astra Läkemedel AB

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

Breast milk and plasma levels of paracetamol were monitored in 3 lactating women after ingestion of a single 500 mg dose of paracetamol. The paracetamol concentrations were consistently lower in milk, with a mean milk/plasma AUC ratio of 0.76. This value was in close agreement with the milk/plasma partition ratio of 0.81 foundin vitro, and could be related to quantitative binding differences between the two fluids. The half-lives of paracetamol in plasma and breast milk were almost identical, with an overall mean of 2.7 h. As less than 0.1% of the maternal dose would be present in 100 ml milk, breast feeding need not be discontinued due to paracetamol treatment in conventional dosage.

Key words

paracetamol breast milk plasma drug excretion in breast milk protein binding