Pharmacokinetics of N-acetylcysteine in man
- L. BorgströmAffiliated withResearch and Development, Pharmacokinetics Laboratory, AB Draco
- , B. KågedalAffiliated withDepartment of Clinical Chemistry, University Hospital
- , O. PaulsenAffiliated withDepartment of Clinical Pharmacology, University Hospital
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N-Acetylcysteine was given intravenously and as three fast dissolving and one slow-release formulation, on separate occasions, as a single dose of 600 mg to 10 fasting (5 men and 5 women) healthy volunteers. Blood and urine were sampled for the following 12 h.
Renal clearance constituted around 30% of total body clearance, which was 0.21 l/h/kg. Volume of distribution was 0.33 l/kg, consistent with distribution mainly to extracellular water. The late elimination half-life was 2.27 h and the mean residence time 1.62 h.
The slow-release tablet resulted in a flattened plasma concentration-time curve typical of slow release formulations, while the other three oral formulations were rapidly absorbed.
The oral availability of N-acetylcysteine varied between 6 and 10%, with the slow-release tablet having the lowest and the fast dissolving tablet the highest availability.
Key wordsN-acetylcysteine bioavailability slow-release formulation pharmacokinetics
- Pharmacokinetics of N-acetylcysteine in man
European Journal of Clinical Pharmacology
Volume 31, Issue 2 , pp 217-222
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- Author Affiliations
- 1. Research and Development, Pharmacokinetics Laboratory, AB Draco, Lund, Sweden
- 2. Department of Clinical Chemistry, University Hospital, Linköping, Sweden
- 3. Department of Clinical Pharmacology, University Hospital, Lund, Sweden