European Journal of Clinical Pharmacology

, Volume 31, Issue 2, pp 217–222

Pharmacokinetics of N-acetylcysteine in man

  • L. Borgström
  • B. Kågedal
  • O. Paulsen
Originals

DOI: 10.1007/BF00606662

Cite this article as:
Borgström, L., Kågedal, B. & Paulsen, O. Eur J Clin Pharmacol (1986) 31: 217. doi:10.1007/BF00606662

Summary

N-Acetylcysteine was given intravenously and as three fast dissolving and one slow-release formulation, on separate occasions, as a single dose of 600 mg to 10 fasting (5 men and 5 women) healthy volunteers. Blood and urine were sampled for the following 12 h.

Renal clearance constituted around 30% of total body clearance, which was 0.21 l/h/kg. Volume of distribution was 0.33 l/kg, consistent with distribution mainly to extracellular water. The late elimination half-life was 2.27 h and the mean residence time 1.62 h.

The slow-release tablet resulted in a flattened plasma concentration-time curve typical of slow release formulations, while the other three oral formulations were rapidly absorbed.

The oral availability of N-acetylcysteine varied between 6 and 10%, with the slow-release tablet having the lowest and the fast dissolving tablet the highest availability.

Key words

N-acetylcysteinebioavailabilityslow-release formulationpharmacokinetics

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • L. Borgström
    • 1
  • B. Kågedal
    • 2
  • O. Paulsen
    • 3
  1. 1.Research and Development, Pharmacokinetics LaboratoryAB DracoLundSweden
  2. 2.Department of Clinical ChemistryUniversity HospitalLinköpingSweden
  3. 3.Department of Clinical PharmacologyUniversity HospitalLundSweden