European Journal of Clinical Pharmacology

, 22:39

Pharmacokinetics of furosemide in neonates

  • P. Vert
  • M. Broquaire
  • M. Legagneur
  • P. L. Morselli
Originals

DOI: 10.1007/BF00606423

Cite this article as:
Vert, P., Broquaire, M., Legagneur, M. et al. Eur J Clin Pharmacol (1982) 22: 39. doi:10.1007/BF00606423

Summary

The pharmacokinetics of furosemide was evaluated in 12 newborns who received the drug transplacentally, and in 21 neonates who received it directly for therapeutic reasons. In the first group, the apparent plasma half-lives ranged from 96 to 6.8 h with a significant inverse relationship (p<0.01) between the gestational age and the elimination rate. In two cases a clear effect on diuresis was also observed. In the neonates receiving the drug i.v. for therapeutic reasons, the elimination kinetics appeared to follow a two-compartment open model, with a significant difference in the therminal plasma half-life between premature (26.8±12.2 h) and full-term newborns (13.4±8.6 h). In this group no relationship was observed between elimination rate and either gestational or conceptional age. In the case of repeated administration, an increase in plasma clearance and reduction in t1/2 β was noticed.

Key words

furosemideneonateskineticsplacental transferintravenous therapy

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • P. Vert
    • 1
  • M. Broquaire
    • 1
  • M. Legagneur
    • 1
  • P. L. Morselli
    • 1
  1. 1.Service de Médecine NéonataleMaternité Régionale UniversitaireNancyFrance
  2. 2.Department of Clinical ResearchL.E.R.S., SynthelaboParisFrance