Diagnostic Neuroradiology

Neuroradiology

, Volume 36, Issue 1, pp 27-30

First online:

Randomised double blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA)

  • P. BrugioresAffiliated withNeuroradiology Department, Hôpital Henri Mondor
  • , A. GastonAffiliated withNeuroradiology Department, Hôpital Henri Mondor
  • , H. R. DegryseAffiliated withUniversity Department of Radiology Ziekenhuis
  • , P. M. ParizelAffiliated withUniversity Department of Radiology Ziekenhuis
  • , A. M. de SchepperAffiliated withUniversity Department of Radiology Ziekenhuis
  • , I. BerryAffiliated withNeuroradiology Department, Hôpital Purpan
  • , C. ManelfeAffiliated withNeuroradiology Department, Hôpital Purpan
  • , F. Le BrasAffiliated withNeuroradiology Department, Hôpital Pitié Salpétrière
  • , C. MarsauhAffiliated withNeuroradiology Department, Hôpital Pitié Salpétrière
    • , W. WichmannAffiliated withAbteilung für Neuroradiologie, Universitätsspital Zürich
    • , A. ValavanisAffiliated withAbteilung für Neuroradiologie, Universitätsspital Zürich

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Abstract

The main difference between macrocyclic Gd-DOTA and linear Gd-DTPA complexes is the greater stability of the former which theoretically might reduce biological interactions in man. To evaluate the clinical relevance of this property, 300 unselected neurological patients were included in a randomised double-blind comparison involving five European centres, focused mainly on the tolerance of these two contrast media. Clinical tolerance was assessed immediatley after the procedure and 24 h later. Adverse events were found with a similar frequency in the two groups (17.3% for Gd-DOTA and 19.3% for Gd-DTPA). Minor neurological symptoms were the most frequent (48.6%) headache being the most common (29.2% of adverse events). No difference in efficacy was found.

Key words

Contrast media MR Comparative studies Gadolinium