Diabetologia

, Volume 34, Supplement 1, pp S113–S117

Follow-up study of sensory-motor polyneuropathy in Type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and kidney transplantation and after graft rejection

  • W. Müller-Felber
  • R. Landgraf
  • St. Wagner
  • N. Mair
  • J. Nusser
  • M. M. C. Landgraf-Leurs
  • A. Abendroth
  • W. -D. Illner
  • W. Land
Neuropathy

DOI: 10.1007/BF00587634

Cite this article as:
Müller-Felber, W., Landgraf, R., Wagner, S. et al. Diabetologia (1991) 34: S113. doi:10.1007/BF00587634

Summary

The influence of successful simultaneous pancreas and kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following kidney-graft-rejection there was a slight decrease of nerve conduction verlocity during the first year, which was not statistically significant. Following pancreas-graft rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-graft-rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s.

In conclusion, we believe that strict normalization of glucose metabolism alters the progressive course of diabetic polyneuropathy. It may be stabilized or partly reversed after successful grafting even in long-term diabetic patients.

Key words

PolyneuropathyDiabetes mellitusPancreas transplantationKidney transplantation

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • W. Müller-Felber
    • 1
    • 3
  • R. Landgraf
    • 1
  • St. Wagner
    • 1
  • N. Mair
    • 1
  • J. Nusser
    • 1
  • M. M. C. Landgraf-Leurs
    • 1
  • A. Abendroth
    • 2
  • W. -D. Illner
    • 2
  • W. Land
    • 2
  1. 1.Department of Internal Medicine “Innenstadt”University of MunichGermany
  2. 2.Transplantation CentreUniversity of MunichGermany
  3. 3.Friedrich-Baur-InstitutMünchen 2Germany