Elasticity as an expression of cross-bridge activity in rat muscle
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Rat soleus muscles (SOL) were isolated and the force-shortening curves were determined during isometric maximal tetani. These were measured by applying sudden shortenings of different magnitudes to one end of the muscle while recording the resulting drop in tension.
From the force-shortening curve a stiffness-force curve was derived. Then a stiffness-force curve was measured by applying small shortenings (20 μm) to the muscle when at different lower stimulation frequencies it was exerting less than maximal tetanic force.
It appeared that the two curves, taken from the same preparations, differed consistently. It was therefore concluded that muscle stiffness at a certain force depends on the way by which this force was reached. This conclusion is shown to fit very well to a sliding filaments model like the one Huxley proposed in 1957.
The sudden shortenings applied to the muscle gave rise to a travelling wave in the muscle. The resulting tension transients could be explained by assuming that muscle behaves as an homogeneous body with distributed mass, stiffness and damping.
- Blangé, T., Karemaker, J. M., Kramer, A. E. J. L.: Tension transients after quick release in rat and frog skeletal muscles. Nature (Lond.)237, 281–282 (1972).
- Close, R.: Dynamic properties of fast and slow skeletal muscles of the rat during development. J. Physiol. (Lond.)173, 74–95 (1964).
- Close, R.: Properties of motor units in fast and slow skeletal muscles of the rat. J. Physiol. (Lond.)193, 45–55 (1967).
- Close, R. I.: Dynamic properties of mammalian skeletal muscles. Physiol. Rev.52, 129–197 (1972).
- Hanson, J., Huxley, H. E.: The structural basis of contraction in striated muscle. Symp. Soc. exp. Biol.9, 228–264 (1955).
- Hemker, H. C., Hermens, W. Th.: Theoretical considerations on a thermodynamic model of muscle action. Cardiovasc. Res. Suppl.1, 84–86 (1971).
- Hill, A. V.: The heat of shortening and the dynamic constants of muscle. Proc. roy. Soc. B126, 136–195 (1938).
- Hill, A. V.: The mechanics of active muscle. Proc. roy. Soc. B141, 104–117 (1953).
- Hill, A. V.: First and last experiments in muscle mechanics. Cambridge: Univ. Press 1970.
- Huxley, A. F.: Muscle structure and theories of contraction. Progr. Biophys. biophys. Chem.7, 257–318 (1957).
- Huxley, A. F., Simmons, R. M.: Proposed mechanism of force generation in striated muscle. Nature (Lond.)233, 533–538 (1971).
- Podolsky, R. J., Nolan, A. C., Zaveler, S. A.: Cross-bridge properties derived from muscle isotonic transients. Proc. nat. Acad. Sci. (Wash.).64, 504–511 (1969).
- Elasticity as an expression of cross-bridge activity in rat muscle
Volume 336, Issue 4 , pp 277-288
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Skeletal Muscle
- Quick Shortening
- Sliding Filaments Model
- Series Elastic Component
- Industry Sectors