Pflügers Archiv

, Volume 323, Issue 1, pp 11–20

Control by insulin of sodium potassium and water excretion by the isolated dog kidney

  • A. Nizet
  • P. Lefebvre
  • J. Crabbé

DOI: 10.1007/BF00586561

Cite this article as:
Nizet, A., Lefebvre, P. & Crabbé, J. Pflugers Arch. (1971) 323: 11. doi:10.1007/BF00586561


Insulin has been shown to decrease sodium, potassium and water excretion by direct action on the kidney. Reduction of sodium excretion is due to enhanced tubular reabsorption as a probable consequence of stimulated active sodium transport. The renal effect of insulin is demonstrated with plasma hormone concentration observable in pathophysiological conditions; it offers therefore a possible explanation for some clinical findings such as the changes in sodium, potassium and water excretion occurring in man after fasting and subsequent glucose feeding.


Insulin Sodium Excretion Potassium Excretion Water Excretion Isolated Kidney 


Insulin Natriumexkretion Kaliumexkretion Wasser-exkretion Isolierte Niere 

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • A. Nizet
    • 1
  • P. Lefebvre
    • 1
  • J. Crabbé
    • 1
    • 2
  1. 1.Institut de MédecineUniversity of LiègeBelgium
  2. 2.Departement de Physiologie et de MédecineUniversité de LouvainLouvain(Belgium)

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