Article

Pflügers Archiv

, Volume 323, Issue 1, pp 11-20

First online:

Control by insulin of sodium potassium and water excretion by the isolated dog kidney

  • A. NizetAffiliated withInstitut de Médecine, University of Liège
  • , P. LefebvreAffiliated withInstitut de Médecine, University of Liège
  • , J. CrabbéAffiliated withInstitut de Médecine, University of LiègeDepartement de Physiologie et de Médecine, Université de Louvain

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Summary

Insulin has been shown to decrease sodium, potassium and water excretion by direct action on the kidney. Reduction of sodium excretion is due to enhanced tubular reabsorption as a probable consequence of stimulated active sodium transport. The renal effect of insulin is demonstrated with plasma hormone concentration observable in pathophysiological conditions; it offers therefore a possible explanation for some clinical findings such as the changes in sodium, potassium and water excretion occurring in man after fasting and subsequent glucose feeding.

Key-Words

Insulin Sodium Excretion Potassium Excretion Water Excretion Isolated Kidney

Schlüsselwörter

Insulin Natriumexkretion Kaliumexkretion Wasser-exkretion Isolierte Niere