Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney
- Cite this article as:
- Schlatter, E., Schurek, HJ. & Zick, R. Pflugers Arch. (1982) 393: 227. doi:10.1007/BF00584074
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Renal handling of pig-and rat-insulin was studied in the isolated perfused rat kidney.
Metabolic clearance rates of both pig- and rat-insulin excceded GFR.
Peritubular uptake of pig-insulin accounted for 13%, of rat-insulin for 31% of the total metabolic clearance.
The nonfiltering kidney does not remove insulin from the peritubular circulation.
Metabolic clearance rates of pig- and rat-insulin are directly related to GFR.
The filtration process seems to be necessary for the uptake of insulin at the peritubular site.