Molecular and General Genetics MGG

, Volume 111, Issue 4, pp 303-316

First online:

Location on the chromosome ofSalmonella typhimurium of genes governing pyrimidine metabolism

  • Christoph F. BeckAffiliated withDepartment of Bacteriology, University of California
  • , John L. IngrahamAffiliated withDepartment of Bacteriology, University of California

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Genes encoding the enzymes cytidine deaminase (cdd), uridine monophosphate pyrophosphorylase (upp), cytidine triphosphate synthetase (pyrG), and uridine phosphorylase (udp) were located on theSalmonella typhimurium chromosome at 68, 77, 90 and 122 min, respectively. Strains carrying mutations inpyrG must also carry mutations incdd in order for cytidine to be sufficiently stable metabolically to supply the cell's requirement for CTP1.