European Journal of Clinical Pharmacology

, Volume 16, Issue 3, pp 171–176

Standardized mental stress in healthy volunteers induced by delayed auditory feedback (DAF)

Authors

  • M. Badian
    • Medical DepartmentClinical Pharmacology, Hoechst AG
  • E. Appel
    • Department of PharmacologyUniversity of Frankfurt
  • D. Palm
    • Department of PharmacologyUniversity of Frankfurt
    • Klinikum der Johann Wolfgang Goethe-Universität Zentrum der Pharmakologie Abteilung IV
  • W. Rupp
    • Medical DepartmentClinical Pharmacology, Hoechst AG
  • W. Sittig
    • Medical DepartmentClinical Pharmacology, Hoechst AG
  • K. Taeuber
    • Medical DepartmentClinical Pharmacology, Hoechst AG
Originals

DOI: 10.1007/BF00562057

Cite this article as:
Badian, M., Appel, E., Palm, D. et al. Eur J Clin Pharmacol (1979) 16: 171. doi:10.1007/BF00562057

Summary

Using delayed auditory feedback (delay 0.175 s) a standardized form of mental stress was investigated in 8 healthy male volunteers. After a resting period and a period of undelayed reading, the volunteers were exposed for 5 min to the DAF stress. During the DAF period heart rate increased by 10% and systolic and diastolic blood pressure increased by 9% and 18%, respectively. As a measure of acute sympathetic activation, plasma concentrations of norepinephrine and epinephrine rose by 68% and 49%, respectively. The activity of dopamine-β-hydroxylase in plasma was increased by 25%. From these results it can be concluded that the DAF procedure provides a suitable method for inducing a standardized mental stress in normal subjects, which can be measured as changes in biochemical and cardiovascular variables.

Key words

mental stresssympathetic activationdelayed auditory feedbackplasma norepinephrineplasma epinephrineplasma dopamine-beta-hydroxylase
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Copyright information

© Springer-Verlag 1979