European Journal of Clinical Pharmacology

, Volume 5, Issue 1, pp 58–61

Absorption and excretion of pralidoxime in man after intramuscular injection of PAM-2CL and various cholinolytics

  • V. B. Vojvodić
  • M. Maksimović
Originals

DOI: 10.1007/BF00560897

Cite this article as:
Vojvodić, V.B. & Maksimović, M. Eur J Clin Pharmacol (1972) 5: 58. doi:10.1007/BF00560897

Summary

A dose of 1.0 g (10.0–14.0 mg/kg body weight) of pralidoxime mixed with various cholinolytics was given by i.m. injection to 29 healthy male subjects. A concentration of pralidoxime in blood of 4 µg/ml was reached after 5 to 10 min with all the mixtures and was maintained for about 1 to 2 h. The calculated half lives of pralidoxime in three groups of subjects were 62.2, 60.0 and 61.8 min., respectively. — The urinary excretions of pralidoxime during the first 4 h after the injections averaged 75.0, 79.6 and 69.6 per cent, respectively, of the total amount given. — The results are compared with published information about similar oximes.

Key words

Pralidoxime chloride pharmacokinetics anti-cholinesterase poisoning 

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • V. B. Vojvodić
    • 1
  • M. Maksimović
    • 1
  1. 1.Department of Pharmacology and Toxicology Institute of Technical and Medical ProtectionBelgradeYugoslavia