European Journal of Clinical Pharmacology

, Volume 35, Issue 3, pp 319–321

Attenuation of cutaneous reactivity to histamine by cetirizine and dexchlorpheniramine

  • F. O. Müller
  • J. J.deK Botha
  • M. van Dyk
  • H. G. Luus
  • G. Groenewoud
Short Communications

DOI: 10.1007/BF00558272

Cite this article as:
Müller, F.O., Botha, J.J., van Dyk, M. et al. Eur J Clin Pharmacol (1988) 35: 319. doi:10.1007/BF00558272

Summary

A double-blind cross-over study was performed in 12 healthy female volunteers comparing cetirizine di-HCl (10 mg) and sustained release dexchlorpheniramine maleate (6 mg) with respect to attentuation of histamine-induced skin wheals and subjective central nervous system (CNS) effects. Cetirizine was significantly more effective than dexchlorpheniramine in suppressing the size of wheals from 2 to 24 h after drug administration. In fact, at 24 h cetirizine was still as affective as 2 h after ingestion. Ten subjects receiving dexchlorpheniramine reported subjective symptoms relating to CNS depression, in contrast to only one subject given cetirizine.

Key words

H1 antagonistscetirizinedexchlorpheniramineskin whealCNS depression

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • F. O. Müller
    • 1
  • J. J.deK Botha
    • 1
  • M. van Dyk
    • 1
  • H. G. Luus
    • 1
  • G. Groenewoud
    • 1
  1. 1.Department of PharmacologyUniversity of the Orange Free StateBloemfonteinRepublic of South Africa