European Journal of Clinical Pharmacology

, Volume 19, Issue 6, pp 431–435

Pharmacokinetics and biotransformation of benzbromarone in man


  • H. Ferber
    • Klinische Pharmakologie1. Medizinische Universitätsklinik
  • H. Vergin
    • Klinische Pharmakologie1. Medizinische Universitätsklinik
  • G. Hitzenberger
    • Klinische Pharmakologie1. Medizinische Universitätsklinik

DOI: 10.1007/BF00548587

Cite this article as:
Ferber, H., Vergin, H. & Hitzenberger, G. Eur J Clin Pharmacol (1981) 19: 431. doi:10.1007/BF00548587


After administration of a single oral dose of benzbromarone 100 mg to 7 subjects, the maximum serum level was 1.84±0.87 mg/l, and the elimination halflife was 2.77±1.07 h. The major metabolite, benzarone, could be detected in serum 3 h after administration of benzbromarone, and the maximum serum benzarone level of 0.79±0.21 mg/l occurred after 6 h. Benzarone had an elimination half-life from serum of 13.52±2.18 h. Both substances were excreted mainly via the liver and bile. In urine only benzarone β-glucuronide could be detected; it amounted to 1.55% of the benzbromarone dose.

Key words

benzbromaronebenzaroneblood levelspharmacokineticsbiotransformationexcretion

Copyright information

© Springer-Verlag 1981