European Journal of Clinical Pharmacology

, Volume 32, Issue 4, pp 419–421

Studies on the central effects of the H1-antagonist, loratadine


  • C. M. Bradley
    • Royal Air Force Institute of Aviation Medicine
  • A. N. Nicholson
    • Royal Air Force Institute of Aviation Medicine
Short Communications

DOI: 10.1007/BF00543979

Cite this article as:
Bradley, C.M. & Nicholson, A.N. Eur J Clin Pharmacol (1987) 32: 419. doi:10.1007/BF00543979


Effects of loratadine (10, 20 and 40 mg) on visuo-motor coordination, dynamic visual acuity, short-term memory, digit symbol substitution, and on subjective assessments of mood were tested before, and 0.5, 1.5, 3.5 and 5.5 h after ingestion by 6 healthy female adults.

There were no effects of 10 or 20 mg loratadine. With 40 mg loratadine the number of substitutions on the digit symbol test was reduced 5.5 h after ingestion, and on dynamic visual acuity response time was increased at 3.5 h and the number of responses missed was increased at 5.5 h.

Triprolidine (10 mg) which was used as active control impaired performance on all the tasks and impaired performance was observed at all times after ingestion.

Loratadine is a promising antihistamine for individuals involved in skilled activity. The anticipated single daily dose of 10 mg is unlikely to impair performance.

Key words

loratadinetriprolidinehistamine antagonistspsycomotor performancememory
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© Springer-Verlag 1987