Studies on the central effects of the H1-antagonist, loratadine
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Effects of loratadine (10, 20 and 40 mg) on visuo-motor coordination, dynamic visual acuity, short-term memory, digit symbol substitution, and on subjective assessments of mood were tested before, and 0.5, 1.5, 3.5 and 5.5 h after ingestion by 6 healthy female adults.
There were no effects of 10 or 20 mg loratadine. With 40 mg loratadine the number of substitutions on the digit symbol test was reduced 5.5 h after ingestion, and on dynamic visual acuity response time was increased at 3.5 h and the number of responses missed was increased at 5.5 h.
Triprolidine (10 mg) which was used as active control impaired performance on all the tasks and impaired performance was observed at all times after ingestion.
Loratadine is a promising antihistamine for individuals involved in skilled activity. The anticipated single daily dose of 10 mg is unlikely to impair performance.
- Borland RG, Nicholson AN (1974) Human performance after a barbiturate. Br J Clin Pharmacol 1: 209–215
- Box GEP, Cox DR (1964) An analysis of transformations. J Statist R Soc 26: 211–232
- Clarke CH, Nicholson AN (1978) Performance studies with antihistamines. Br J Clin Pharmacol 6: 31–35
- Kaiser HF (1958) The varimax criterion for analytic rotation in factor analysis. Psychometrika 23: 187–200
- Nicholson AN (1979) Effect of the antihistamines, brompheniramine maleate and triprolidine hydrochloride, on performance in man. Br J Clin Pharmacol 8: 321–324
- Nicholson AN (1982) Antihistaminic activity and central effects of terfenadine. Arzneimittelforsch/Drug Res 32: 1191–1193
- Nicholson AN (1985) Central effects of H1- and H2-antihistamines. Aviat Space Environ Med 56: 293–298
- Nicholson AN, Stone BM (1982) Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine. Br J Clin Pharmacol 13: 199–202
- Nicholson AN, Stone BM (1982) Hypnotic activity and effects on performance of lormetazepam and camazepam — analogues of temazepam. Br J Clin Pharmacol 13: 433–439
- Nicholson AN, Stone BM (1983) The H1-antagonist mequitazine: Studies on performance and visual function. Eur J Clin Pharmacol 25: 563–566
- Nicholson AN, Smith PA, Spencer MB (1982) Antihistamines and visual function: Studies on dynamic acuity and the pupillary response to light. Br J Clin Pharmacol 14: 683–690
- Studies on the central effects of the H1-antagonist, loratadine
European Journal of Clinical Pharmacology
Volume 32, Issue 4 , pp 419-421
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