European Journal of Clinical Pharmacology

, Volume 22, Issue 2, pp 137–142

A comparison of the psychotropic profiles of tofisopam and diazepam

  • A. Bond
  • M. Lader
Originals

DOI: 10.1007/BF00542458

Cite this article as:
Bond, A. & Lader, M. Eur J Clin Pharmacol (1982) 22: 137. doi:10.1007/BF00542458

Summary

Twelve normal subjects were tested on a number of measures both before and 1,3 and 5 h after 10 mg diazepam, 100 and 200 mg tofisopam and a placebo. The measures included self-ratings of mood, bodily symptoms, hostility and sleep, the electroencephalogram (EEG), reaction time, tapping, digit symbol substitution, the symbol copying test, and plasma levels. Diazepam showed a clear profile of action, producing EEG changes, pronounced sedation and psychological impairment. The last two effects were maximal at 1 h and had worn off by 5 h. The EEG was recorded at 3 h only. Tofisopam in no way resembled diazepam. It produced no changes on the EEG or psychological tests and a very mild stimulant effect was apparent on the ratings. While diazepam was easily detectable in the blood, tofisopam did not bind to benzodiazepine receptors.

Key words

tofisopamdiazepamelectroencephalogramsedationpro-drug

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Bond
    • 1
  • M. Lader
    • 1
  1. 1.Department of Pharmacology, Institute of PsychiatryUniversity of LondonEngland