European Journal of Clinical Pharmacology

, Volume 25, Issue 5, pp 615–620

Corticosteroid-induced bone loss. A longitudinal study of alternate day therapy in patients with bronchial asthma using quantitative computed tomography

Authors

  • P. Rüegsegger
    • Institute for Biomedical EngineeringUniversity of Zürich and Federal Institute of Technology
    • Department of Internal MedicineUniversity Hospital
  • T. C. Medici
    • Institute for Biomedical EngineeringUniversity of Zürich and Federal Institute of Technology
    • Department of Internal MedicineUniversity Hospital
  • M. Anliker
    • Institute for Biomedical EngineeringUniversity of Zürich and Federal Institute of Technology
    • Department of Internal MedicineUniversity Hospital
Originals

DOI: 10.1007/BF00542348

Cite this article as:
Rüegsegger, P., Medici, T.C. & Anliker, M. Eur J Clin Pharmacol (1983) 25: 615. doi:10.1007/BF00542348

Summary

Treatment with corticosteroids can produce osteoporosis. It is generally held that bone loss occurs when steroids are administered daily, but recent findings indicate that bone may also be lost on alternate day therapy. Cortical and trabecular bone, which may be affected differently, can be assessed independently, by quantitative computed tomography. This technique has been applied to the appendicular skeleton in following 20 patients with bronchial asthma during one year of chronic alternate day corticosteroid therapy. The trabecular bone loss was considerable; prednisone 25 mg on alternate days caused an average reduction in trabecular bone of 3.5% over one year. Bone loss was dose- and agedependent. Young patients on 50 mg/2 days lost up to 17% trabecular bone in one year. Cortical bone was not significantly affected over the same period.

Key words

osteoporosiscorticosteroid therapyquantitative computed tomographyasthmabone densitometryprednisoneage effectdose-response relationship
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Copyright information

© Springer-Verlag 1983