Internationales Archiv für Arbeitsmedizin

, Volume 32, Issue 1, pp 85–91

Respiratory elimination of organic solvents in man

Benzene, toluene, n-hexane, trichloroethylene, acetone, ethyl acetate and ethyl alcohol

Authors

  • Kazuo Nomiyama
    • Department of HygieneGunma University School of Medicine
  • Hiroko Nomiyama
    • Department of HygieneGunma University School of Medicine
Article

DOI: 10.1007/BF00539098

Cite this article as:
Nomiyama, K. & Nomiyama, H. Int. Arch. Arbeitsmed (1974) 32: 85. doi:10.1007/BF00539098

Summary

Respiratory elimination of benzene, toluene, n-hexane, trichloroethylene, acetone, ethyl acetate and ethyl alcohol were studied after exposure in human volunteers to those solvents.
  1. 1.

    Solvent concentration in expired air decreased rapidly with time after the cessation of exposure and the decrease was expressed as an equation. Ethyl acetate and ethyl alcohol in expired air decreased faster than did other organic solvents. The decrease was very slow in acetone.

     
  2. 2.

    Large amounts of retained acetone, benzene and n-hexane were eliminated through the lungs as unchanged solvents, while the amount of eliminated ethyl acetate was almost negligible.

     
  3. 3.

    The ratio of respiratory elimination to the inhaled (environmental) organic solvent suggested that the determination of respiratory concentration is helpful for estimating environmental benzene, acetone, trichloroethylene and toluene concentration.

     

Key words

HumanOrganic solventEliminationSex differenceRespirationBenzeneToluenen-HexaneTrichloroethyleneAcetoneEthyl acetateEthyl alcohol

Copyright information

© Springer-Verlag 1974