Mammalian Genome

, Volume 6, Issue 11, pp 763–768

A high-resolution genetic map of mouse Chromosome 15 encompassing the Dominant megacolon (Dom) locus

  • A. Puliti
  • M. O. Prehu
  • D. Simon-Chazottes
  • L. Ferkdadji
  • M. Peuchmaur
  • M. Goossens
  • J. L. Guénet
Original Contributions

DOI: 10.1007/BF00539000

Cite this article as:
Puliti, A., Prehu, M.O., Simon-Chazottes, D. et al. Mammalian Genome (1995) 6: 763. doi:10.1007/BF00539000

Abstract

Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra- and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus.

Copyright information

© Springer-Verlag New York Inc. 1995

Authors and Affiliations

  • A. Puliti
    • 1
  • M. O. Prehu
    • 1
  • D. Simon-Chazottes
    • 2
  • L. Ferkdadji
    • 3
  • M. Peuchmaur
    • 3
  • M. Goossens
    • 1
  • J. L. Guénet
    • 2
  1. 1.Unité INSERM U91Hôpital Henri MondorCréteil CedexFrance
  2. 2.Unité de Génétique des MammifèresInstitut PasteurParisFrance
  3. 3.Service d'anatomie-pathologiqueHôpital Robert DebréParisFrance