Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 323, Issue 4, pp 341–342

Capsaicin pretreatment inhibits heat-induced oedema in the rat skin

  • Alois Saria
  • Jan M. Lundberg

DOI: 10.1007/BF00512473

Cite this article as:
Saria, A. & Lundberg, J.M. Naunyn-Schmiedeberg's Arch. Pharmacol. (1983) 323: 341. doi:10.1007/BF00512473


Exposure of rat paws to noxious heat (hot water, 48°C) led to an increase in vascular permeability to macromolecules as indicated by extravasation of Evans blue dye. After pretreatment of neonatal rats with 50 mg · kg−1 capsaicin s.c., which is known to cause degeneration of unmyelinated afferent neurones, this protein leakage was reduced by 74% (P<0.01). It is concluded that the oedema induced by noxious heat is partially caused by excitation of peripheral endings of capsaicin-sensitive primary afferent neurones.

Key words

Thermal injury Vascular protein leakage Capsaicin 

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Alois Saria
    • 1
  • Jan M. Lundberg
    • 1
  1. 1.Department of PharmacologyKarolinska InstitutetStockholmSweden
  2. 2.Department of Experimental and Clinical PharmacologyUniversity of GrazGrazAustria