Capsaicin pretreatment inhibits heat-induced oedema in the rat skin
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- Saria, A. & Lundberg, J.M. Naunyn-Schmiedeberg's Arch. Pharmacol. (1983) 323: 341. doi:10.1007/BF00512473
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Exposure of rat paws to noxious heat (hot water, 48°C) led to an increase in vascular permeability to macromolecules as indicated by extravasation of Evans blue dye. After pretreatment of neonatal rats with 50 mg · kg−1 capsaicin s.c., which is known to cause degeneration of unmyelinated afferent neurones, this protein leakage was reduced by 74% (P<0.01). It is concluded that the oedema induced by noxious heat is partially caused by excitation of peripheral endings of capsaicin-sensitive primary afferent neurones.