Archives of Dermatological Research

, Volume 282, Issue 1, pp 38–41

The inhibiting effect of PABA on photocarcinogenesis


  • H. Flindt-Hansen
    • Department of DermatologyUllevaal Hospital, University of Oslo
  • P. Thune
    • Department of DermatologyUllevaal Hospital, University of Oslo
  • T. Eeg Larsen
    • Department of PathologyUllevaal Hospital, University of Oslo
Original Contributions

DOI: 10.1007/BF00505643

Cite this article as:
Flindt-Hansen, H., Thune, P. & Eeg Larsen, T. Arch Dermatol Res (1990) 282: 38. doi:10.1007/BF00505643


The efficacy of a 5% solution of para-aminobenzoic acid (PABA) to protect against photocarcinogenesis was tested in 6 groups, each of which contained 30 light pigmented hairless mice. The light source was a Phillips TL 40 W/12, which mainly emits UVB. PABA significantly retarded the tumor induction time (p<0.05) and reduced both tumor yield and carcinoma yield (p<0.05). The dorsal skin of the mice was removed and weighed. The mean weight of UVR-exposed mice skin protected with PABA did not differ from that of the controls, but in the non-protected UVR-exposed mice the skin samples were significantly heavier (p<0.05).

Key words

PABASunscreening agentUltraviolet carcinogenesis
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© Springer-Verlag 1990