Archives of Dermatological Research
, Volume 282, Issue 1, pp 38-41
First online:
The inhibiting effect of PABA on photocarcinogenesis
- H. Flindt-HansenAffiliated withDepartment of Dermatology, Ullevaal Hospital, University of Oslo
- , P. ThuneAffiliated withDepartment of Dermatology, Ullevaal Hospital, University of Oslo
- , T. Eeg LarsenAffiliated withDepartment of Pathology, Ullevaal Hospital, University of Oslo
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The efficacy of a 5% solution of para-aminobenzoic acid (PABA) to protect against photocarcinogenesis was tested in 6 groups, each of which contained 30 light pigmented hairless mice. The light source was a Phillips TL 40 W/12, which mainly emits UVB. PABA significantly retarded the tumor induction time (p<0.05) and reduced both tumor yield and carcinoma yield (p<0.05). The dorsal skin of the mice was removed and weighed. The mean weight of UVR-exposed mice skin protected with PABA did not differ from that of the controls, but in the non-protected UVR-exposed mice the skin samples were significantly heavier (p<0.05).
Key words
PABA Sunscreening agent Ultraviolet carcinogenesis- Title
- The inhibiting effect of PABA on photocarcinogenesis
- Journal
-
Archives of Dermatological Research
Volume 282, Issue 1 , pp 38-41
- Cover Date
- 1990-01
- DOI
- 10.1007/BF00505643
- Print ISSN
- 0340-3696
- Online ISSN
- 1432-069X
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
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- PABA
- Sunscreening agent
- Ultraviolet carcinogenesis
- Industry Sectors
- Authors
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- H. Flindt-Hansen (1)
- P. Thune (1)
- T. Eeg Larsen (2)
- Author Affiliations
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- 1. Department of Dermatology, Ullevaal Hospital, University of Oslo, Oslo 4, Norway
- 2. Department of Pathology, Ullevaal Hospital, University of Oslo, Oslo 4, Norway