, Volume 82, Issue 1, pp 5-8

First online:

Suggestive evidence for a functional unit between mast cells and substance P fibers in the rat diaphragm and mesentery

  • G. SkofitschAffiliated withLaboratory of Clinical Science, NIMH
  • , J. M. SavittAffiliated withLaboratory of Clinical Science, NIMH
  • , D. M. JacobowitzAffiliated withLaboratory of Clinical Science, NIMH

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A close spatial relationship between serotonin-containing mast cells and substance P-containing nerves was shown by immunohistochemistry using a combination of antisera specific for serotonin and substance P. This supports earlier morphological results suggesting an innervation of mast cells and pharmacological studies which postulate an influence of substance P on the release of histamine from mast cells.