Distribution of CAIII in fetal and adult human tissue
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Carbonic anhydrase III (CAIII), an enzyme recently shown by conventional electrophoresis to be muscle specific, has been quantitated by “rocket” immunoelectrophoresis. This more sensitive technique has shown that the enzyme is virtually specific to skeletal muscle, where it occurs at a level of 5mg/g, with trace levels in smooth muscle, cardiac muscle, and lung. In man there does not appear to by any correlation between CAIII levels and the proportion of red and white muscle fibers. The fetal development of CAIII has also been examined using immunoelectrophoresis, and the enzyme can be detected at 11 weeks' gestation. The CAIII level rises gradually up to 25 weeks, and there is then a more dramatic increase to reach approximately half adult level at birth.
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- Distribution of CAIII in fetal and adult human tissue
Volume 18, Issue 9-10 , pp 843-849
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- carbonic anhydrase
- fetal development
- Author Affiliations
- 1. Department of Child Health, St George's Hospital Medical School, Cranmer Terrace, SW17 ORE, London, England
- 2. MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, NW1 2HE, London, England