125I-Labelled botulinum a neurotoxin: Pharmacokinetics in cats after intramuscular injection
- H. WiegandAffiliated withPharmakologisches Institut der Justus Liebig-Universität
- , G. ErdmannAffiliated withPharmakologisches Institut der Justus Liebig-Universität
- , H. H. WellhönerAffiliated withPharmakologisches Institut der Justus Liebig-Universität
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On unilateral injection of sublethal doses of 125I-botulinum A neurotoxin (BTA) into one gastrocnemius muscle of the cat we found after 48 h:
A disto-proximal gradient of radioactivity (RA) had developed in the sciatic nerve of the injected side.
The ventral roots of the spinal cord half segments supplying the injected muscle showed a higher RA than the ventral roots of the contralateral control side.
The spinal cord half segments innervating the injected muscle had a RA much higher than the corresponding segments of the contralateral side. However, a small rise of RA was also observed in the contralateral half segments.
In histoautoradiographs of the (ligatured) ventral roots the RA was strictly confined to the intraaxonal space of a few nerve fibres.
On injection of equal doses of 125I-BTA into either gastrocnemius muscle we found after 38 h:
Direct stimulation of only one of the injected muscles caused the RA to reach a higher level in the spinal cord half segments ipsilateral to the stimulated muscle than in the spinal cord half segments of the non-stimulated side.
Unilateral stimulation of one gastrocnemius nerve under the influence of gallamine or unilateral antidromic stimulation of the dorsal roots L7, S1 failed to cause a difference in RA between stimulated and non-stimulated side.
Key wordsBotulinum A toxin Pharmacokinetics Neural ascent Neuromuscular activity
- 125I-Labelled botulinum a neurotoxin: Pharmacokinetics in cats after intramuscular injection
Naunyn-Schmiedeberg's Archives of Pharmacology
Volume 292, Issue 2 , pp 161-165
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- Botulinum A toxin
- Neural ascent
- Neuromuscular activity
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