125I-Labelled botulinum a neurotoxin: Pharmacokinetics in cats after intramuscular injection
- Cite this article as:
- Wiegand, H., Erdmann, G. & Wellhöner, H.H. Naunyn-Schmiedeberg's Arch. Pharmacol. (1976) 292: 161. doi:10.1007/BF00498587
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On unilateral injection of sublethal doses of 125I-botulinum A neurotoxin (BTA) into one gastrocnemius muscle of the cat we found after 48 h:
A disto-proximal gradient of radioactivity (RA) had developed in the sciatic nerve of the injected side.
The ventral roots of the spinal cord half segments supplying the injected muscle showed a higher RA than the ventral roots of the contralateral control side.
The spinal cord half segments innervating the injected muscle had a RA much higher than the corresponding segments of the contralateral side. However, a small rise of RA was also observed in the contralateral half segments.
In histoautoradiographs of the (ligatured) ventral roots the RA was strictly confined to the intraaxonal space of a few nerve fibres.
On injection of equal doses of 125I-BTA into either gastrocnemius muscle we found after 38 h:
Direct stimulation of only one of the injected muscles caused the RA to reach a higher level in the spinal cord half segments ipsilateral to the stimulated muscle than in the spinal cord half segments of the non-stimulated side.
Unilateral stimulation of one gastrocnemius nerve under the influence of gallamine or unilateral antidromic stimulation of the dorsal roots L7, S1 failed to cause a difference in RA between stimulated and non-stimulated side.