Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 313, Issue 2, pp 151–153

α2-Adrenoceptors modulating insulin release from isolated pancreatic islets

  • Toshio Nakaki
  • Teruo Nakadate
  • Ryuichi Kato
Article

DOI: 10.1007/BF00498572

Cite this article as:
Nakaki, T., Nakadate, T. & Kato, R. Naunyn-Schmiedeberg's Arch. Pharmacol. (1980) 313: 151. doi:10.1007/BF00498572

Summary

Using rat isolated pancreatic islets, we investigated the effects of various α-adrenoceptor blocking agents on adrenaline-induced inhibition of glucose-stimulated insulin release. Yohimbine was about 100 times more potent than prazosin in antagonizing the inhibitory effect of adrenaline. At concentrations of 10 μM, phentolamine was about as effective as an antagonist as yohimbine, whereas dihydroergotamine, WB-4101 and phenoxybenzamine were less effective and prazosin produced very little antagonism. These results strongly suggest that postsynaptic α2-adrenoceptors modulate insulin release from pancreatic islets.

Key words

Pancreatic islets Insulin release Yohimbine Prazosin Postsynaptic α2-adrenoceptors 

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Toshio Nakaki
    • 1
  • Teruo Nakadate
    • 1
  • Ryuichi Kato
    • 1
  1. 1.Department of Pharmacology, School of MedicineKeio UniversityTokyoJapan

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