Biochemical Genetics

, Volume 22, Issue 7, pp 657–667

Multiple gene action determining a mouse salivary protein phenotype: Identification of the structural gene for androgen binding protein (Abp)

  • Stephen R. Dlouhy
  • Robert C. Karn
Article

DOI: 10.1007/BF00485851

Cite this article as:
Dlouhy, S.R. & Karn, R.C. Biochem Genet (1984) 22: 657. doi:10.1007/BF00485851

Abstract

A novel variation in electrophoretic phenotype is described for a mouse salivary androgen binding protein (Abp). Crosses show that the variation is inherited in an autosomal codominant manner and protein characterization studies show that the variant Abp differs in isoelectric point from the common form of the protein. Those observations suggest that the variation involves the structural gene for the mouse salivary Abp. The genetic studies also show that the electrophoretic mobility of the variant Abp can be influenced by the sex-limited saliva pattern (Ssp) gene. The SspS allele alters the electrophoretic mobility of Abp in males at puberty or in females which have received exogenous testosterone [Karn, R. C., Dlouhy, S. R., Springer, K. R., Hjorth, J. P., and Nielsen, J. T. (1982). Biochem Genet. 20:493]. This study shows that Abp and Ssp are distinct genes which are not closely linked and that SspS is trans active in F1 (Abpa/Abpb, SspS/SspF) males.

Key words

androgen binding proteins mouse salivary proteins structural gene variation 

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Stephen R. Dlouhy
    • 1
  • Robert C. Karn
    • 1
  1. 1.Department of Medical GeneticsIndiana University School of MedicineIndianapolis

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