Biochemical Genetics

, Volume 20, Issue 5, pp 493–504

Sex-limited genetic variation in a mouse salivary protein

  • Robert C. Karn
  • Stephen R. Dlouhy
  • Kenneth R. Springer
  • J. Peter Hjorth
  • J. Tønnes Nielsen
Article

DOI: 10.1007/BF00484700

Cite this article as:
Karn, R.C., Dlouhy, S.R., Springer, K.R. et al. Biochem Genet (1982) 20: 493. doi:10.1007/BF00484700

Abstract

This report describes a gene which influences the electrophoretic mobility of a protein in the salivas of adult mice. Three categories of phenotype have been observed: the two single-banded types, F (Fast) and S (Slow), and the two-banded type, SF (Slow-Fast), with the two bands represented in varying proportions. All females, regardless of age or strain, and all males before puberty show only the F phenotype. Males of the BALB/c and C57BL/6J strains show the F phenotype throughout puberty and adult life, whereas males of the C3H/St and C57BL/KsJ strains show the SF phenotype in puberty and the S phenotype in adult life. We have designated this variation the sex-limited saliva pattern (Ssp). The results from genetic crosses indicate that the variation among the strains is determined by an autosomal locus, Ssp, with two alleles, SspS andSspF,where SspSis dominant to SspF.Testosterone treatment can accelerate the acquisition of the S type in males of the strains C3H/St and C57BL/KsJ and also induces that phenotype in C3H/St females and C57BL/6J males. Thus it appears that the observed strain-specific differences reflect a genetic variation in androgen levels and/or androgen sensitivity rather than variation in a structural gene.

Key words

mouse salivary proteins electrophoresis testosterone sex-limited variation 

Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Robert C. Karn
    • 1
  • Stephen R. Dlouhy
    • 1
  • Kenneth R. Springer
    • 1
  • J. Peter Hjorth
    • 2
  • J. Tønnes Nielsen
    • 2
  1. 1.Department of Medical GeneticsIndiana University School of MedicineIndianapolis
  2. 2.Department of Molecular BiologyUniversity of AarhusAarhus CDenmark

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