Statistical analysis of bioassays, based on hazard modelling
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A stochastic model is proposed to describe time-dependent lethal effects of toxic compounds. It is based on simple mechanistic assumptions and provides a measure for the toxicity of a chemical compound, the so-called killing rate. The killing rate seems a promising alternative for the LC50. The model also provides the no-effect level and the LC50, both as a function of exposure time. The model is applied to real data and to simulated data.
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- Statistical analysis of bioassays, based on hazard modelling
Environmental and Ecological Statistics
Volume 1, Issue 4 , pp 303-314
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- Online ISSN
- Kluwer Academic Publishers
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- killing rate
- maximum likelihood
- no-effect level
- one-compartment model
- quantal assay data
- time dependent toxicity