Archives of oto-rhino-laryngology

, Volume 243, Issue 4, pp 238–241

The cochlea of the spontaneously diabetic mouse

I. Electron microscopic observation of KK mice

Authors

  • M. Tachibana
    • Department of OtolaryngologyKyoto Prefectural University of Medicine Kawaramachi Hirokoji
  • S. Nakae
    • Department of OtolaryngologyKyoto Prefectural University of Medicine Kawaramachi Hirokoji
Article

DOI: 10.1007/BF00464437

Cite this article as:
Tachibana, M. & Nakae, S. Arch Otorhinolaryngol (1986) 243: 238. doi:10.1007/BF00464437

Summary

We examined the cochleae of the spontaneously diabetic KK mice by using transmission electron microscopy. At the age of 3 months, the mice started to show evidence for glycosuria and hyperglycemia, and tissue sections showed beginning cochlear pathology. The pathological changes present were found to be limited to the stria vascularis: protrusions of marginal cells, swellings of intermediate cells and widening of intercellular spaces were the main findings seen. These changes progressed with age, but were not observed in age-matched nondiabetic 57BL/6 mice. The possible mechanism of diabetes causing cochlear pathology is discussed.

Key words

Diabetes mellitus KK mice Cochlea Transmission electron microscope

Copyright information

© Springer-Verlag 1986