Archives of oto-rhino-laryngology

, Volume 238, Issue 3, pp 217–223

The sensitive period for ototoxicity of kanamycin in mice: Morphological evidence

  • C.-S. Chen
  • J. C. Saunders

DOI: 10.1007/BF00453932

Cite this article as:
Chen, CS. & Saunders, J.C. Arch Otorhinolaryngol (1983) 238: 217. doi:10.1007/BF00453932


The ototoxicity of kanamycin was investigated in mice treated with the drug either from 6 to 9, 10 to 13, or 15 to 18 days of age. The results showed extensive damage to the outer-hair-cell (OHC) receptors of the cochlea in the 10–13-day group; some less severe damage to the OHC was found in the 6–9-day group, and little damage was observed in the 15–18 day group. The present finding is consistent with the view that the mouse cochlea is most vulnerable to the ototoxic effect of kanamycin during the period of its rapid development, i.e., between 10 and 13 days of age.

Key words

Kanamycin Cochlea damage Audiogenic seizures Sensitive period for ototoxicity Mice 

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • C.-S. Chen
    • 1
  • J. C. Saunders
    • 1
  1. 1.Department of Otorhinolaryngology and Human CommunicationUniversity of PennsylvaniaPennsylvaniaUSA
  2. 2.Department of PsychologyMonash UniversityClaytonAustralia

Personalised recommendations