Psychopharmacology

, Volume 98, Issue 3, pp 297–303

Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG)

  • W. Dimpfel
  • M. Spüler
  • D. E. Nichols
Original Investigations

DOI: 10.1007/BF00451678

Cite this article as:
Dimpfel, W., Spüler, M. & Nichols, D.E. Psychopharmacology (1989) 98: 297. doi:10.1007/BF00451678

Abstract

Telemetric recordings of field potentials from frontal cortex, hippocampus, striatum and reticular formation of freely moving rats were analysed before and after injection of the enantiomeric hallucinogenic amphetamine derivatives R-DOB [(−)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane], R-DOM [(−)-1-(2,5-dimethoxy-4-methylphenyl)-2-amino-propane] and R-DOI [(−)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropanel] as well as the nonhallucinogenic amphetamine derivatives S-MBDB [(+)-N-methyl-1-(1,3-benzodioxol-5-yl)butanamine] and S-MDMA [(+)-3,4-methylenedioxymethamphetamine] and S-(+)-amphetamine. The frequency analysis of the field potentials revealed a clearcut difference between them. The spectral patterns emerging after injection of the non-hallucinogens were characterized by a general decrease of power, the changes in the alpha2 and delta band being the most prominent, whereas only after the application of the hallucinogenic compounds was a contrasting increase of power observed in the alpha1 frequency band, especially in the striatum. As increases in alpha1 power have been correlated in the same pharmacological model to serotonergic control mechanisms, the results are in line with the hypothesis that 5-HT2 receptors, predominantly occurring in the striatum, might be involved in the hallucinogenic action of drugs.

Key words

HallucinogenicsAmphetamineRatTele-Stereo-EEG

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • W. Dimpfel
    • 1
  • M. Spüler
    • 1
  • D. E. Nichols
    • 2
  1. 1.Pro Science Private Research Institute GmbHLindenFederal Republic of Germany
  2. 2.Department of Medical and Chemical PharmacognosyPurdue UniversityWest LafayetteUSA