European Journal of Pediatrics

, Volume 138, Issue 4, pp 341–344

Clinical and immunological response to oral and subcutaneous immunotherapy with grass pollen extracts

A prospective study
  • W. Rebien
  • E. Puttonen
  • H. J. Maasch
  • E. Stix
  • U. Wahn
Original Investigations

DOI: 10.1007/BF00442513

Cite this article as:
Rebien, W., Puttonen, E., Maasch, H.J. et al. Eur J Pediatr (1982) 138: 341. doi:10.1007/BF00442513

Abstract

Forty children allergic to grass pollen were divided into two groups, and matched by their serum IgE antibody concentrations to grasses. For two preseasonal treatment periods one group received immunotherapy with an alum adsorbed grass pollen extract, while the second group was treated orally with an aqueous extract of the same allergens.

The patients' postseasonal self evaluation as well as the mean symptom scores calculated from symptom diaries indicate, that oral treatment is significantly less effective in controlling seasonal allergic symptoms than subcutaneous immunotherapy. During oral treatment neither an increase of specific serum IgG antibodies, nor a suppression of the seasonal increase in specific serum IgE antibodies could be demonstrated.

Key words

ImmunotherapyPollen allergyIgEIgG

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • W. Rebien
    • 1
  • E. Puttonen
    • 2
  • H. J. Maasch
    • 2
  • E. Stix
    • 3
  • U. Wahn
    • 1
  1. 1.Universitätskinderklinik HeidelbergFederal Republic of Germany
  2. 2.AllergopharmaReinbekFederal Republic of Germany
  3. 3.UmweltbundesamtBerlin
  4. 4.Allgem. Krankenhaus HeidbergHamburg