European Journal of Pediatrics

, Volume 138, Issue 4, pp 327–330

Thyroid function in children with cystic fibrosis

  • F. De Luca
  • F. Trimarchi
  • C. Sferlazzas
  • S. Benvenga
  • G. Costante
  • C. Mami
  • G. Di Pasquale
  • G. Magazzu
Original Investigations

DOI: 10.1007/BF00442510

Cite this article as:
De Luca, F., Trimarchi, F., Sferlazzas, C. et al. Eur J Pediatr (1982) 138: 327. doi:10.1007/BF00442510

Abstract

Serum concentrations of T4, T3, reverse T3 (rT3), TSH, Thyroxine binding globulin (TBG) and Thyroxine binding prealbumin (TBPA) were measured and a TRH-stimulation test was performed in 10 iodide untreated children affected by cystic fibrosis (CF) and in 84 controls.

As compared to the controls, CF patients had lower T4 and rT3, similar T3 and TBG and increased T3:T4 ratios. They also had lower TBPA, but this could not account for the low T4. Finally they had higher basal and TRH-stimulated TSH. Our results indicate subclinical hypothyroidism in CF. The mechanisms responsible for this situation are not elucidated by our data.

Key words

Cystic fibrosisThyroid hormonesThyrotropinThyroxine binding globulinThyroxine binding prealbuminTRH test-iodides

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • F. De Luca
    • 1
  • F. Trimarchi
    • 2
  • C. Sferlazzas
    • 1
  • S. Benvenga
    • 2
  • G. Costante
    • 2
  • C. Mami
    • 1
  • G. Di Pasquale
    • 1
  • G. Magazzu
    • 1
  1. 1.2nd Clinica PediatricaUniversity of MessinaItaly
  2. 2.1st Clinica MedicaUniversity of MessinaItaly