European Journal of Pediatrics

, Volume 135, Issue 3, pp 291–292

Familial occurrence of meconium ileus

Authors

  • Jean L. Allan
    • Department of Thoracic MedicineRoyal Children's Hospital
    • Department of PaediatricsUniversity of Melbourne
  • Melissa Robbie
    • Department of Thoracic MedicineRoyal Children's Hospital
    • Department of PaediatricsUniversity of Melbourne
  • P. D. Phelan
    • Department of Thoracic MedicineRoyal Children's Hospital
    • Department of PaediatricsUniversity of Melbourne
  • D. M. Danks
    • Department of Thoracic MedicineRoyal Children's Hospital
    • Department of PaediatricsUniversity of Melbourne
Original Investigations

DOI: 10.1007/BF00442105

Cite this article as:
Allan, J.L., Robbie, M., Phelan, P.D. et al. Eur J Pediatr (1981) 135: 291. doi:10.1007/BF00442105

Abstract

A recurrence rate for meconium ileus of 39% was found among C.F. affected siblings in a study of 488 families with at least one C.F. child born over a 24 year period. The recurrence rate was highly significant and indicated a familial trend for the occurrence of meconium ileus. The findings of the study support the existence of genetic heterogeneity in cystic fibrosis.

Key words

Meconium ileusCystic fibrosisGenetic heterogeneity

Copyright information

© Springer-Verlag 1981