European Journal of Pediatrics

, Volume 144, Issue 4, pp 395–398

Diphtheritic septicaemia and probable endocarditis: A case report and review of the literature

  • S. Sirinavin
  • P. Suthas-Na-Aynthaya
Original Investigations

DOI: 10.1007/BF00441786

Cite this article as:
Sirinavin, S. & Suthas-Na-Aynthaya, P. Eur J Pediatr (1985) 144: 395. doi:10.1007/BF00441786

Abstract

Corynebacterium diphtheriae usually produces an infection limited to the respiratory tract and the organisms rarely invade the blood stream. We report the case of a 6-year-old girl who, 2 months after an unsuccessful repair of a ventricular septal defect, developed septicaemia with nontoxigenic C. diphtheriae. The organism appeared resistant to penicillin in vitro and failed to respond to a course of trimethoprim-sulfamethoxazole to which it was susceptible in the laboratory. A cure was finally achieved using cephalothin and gentamicin, followed by an additional course of ampicillin and amoxicillin. Twelve previously recorded cases of diphtheritic sepsis and endocarditis are reviewed.

Key words

Diphtheria Endocarditis Septicaemia 

Abbreviations

VSD

ventricular-septal defect

TMS

trimethoprim-sulfamethoxazole

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • S. Sirinavin
    • 1
  • P. Suthas-Na-Aynthaya
    • 2
  1. 1.Division of Infectious Disease, Department of Pediatrics, Faculty of Medicine, Ramathibodi HospitalMahidol UniversityBangkokThailand
  2. 2.Division of Cardiology, Department of Pediatrics, Faculty of Medicine, Ramathibodi HospitalMahidol UniversityBangkokThailand

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