HLA frequencies and haplotypes in children with idiopathic thrombocytopenic purpura (ITP)
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- Evers, KG., Thouet, R., Haase, W. et al. Eur J Pediatr (1978) 129: 267. doi:10.1007/BF00441357
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26 patients with an acute reversible ITP and 6 with chronic ITP were tissue typed, together with their healthy first-degree relatives. The HLA frequencies of the different groups were compared with those of a normal control population. The only significant difference between the groups was an increase in the frequency of Aw32 in acute ITP patients. HLA-Aw32 was present in 26.9% of patients, but in only 0.8% of the controls (corrected P=0.000027). The possible importance of associations between antigens of the HLA-A locus with certain diseases are discussed. Family analyses and haplotype determinations proved to be unproductive because no familial clustering of ITP was found.