European Journal of Pediatrics

, Volume 129, Issue 4, pp 267–272

HLA frequencies and haplotypes in children with idiopathic thrombocytopenic purpura (ITP)


  • K.-G. Evers
    • Children's Hospital of the City of Cologne
  • R. Thouet
    • Institute of Numerical Statistics
  • W. Haase
    • Institute of Numerical Statistics
  • J. Krüger
    • Department of Blood Transfusion of the University of Cologne

DOI: 10.1007/BF00441357

Cite this article as:
Evers, K., Thouet, R., Haase, W. et al. Eur J Pediatr (1978) 129: 267. doi:10.1007/BF00441357


26 patients with an acute reversible ITP and 6 with chronic ITP were tissue typed, together with their healthy first-degree relatives. The HLA frequencies of the different groups were compared with those of a normal control population. The only significant difference between the groups was an increase in the frequency of Aw32 in acute ITP patients. HLA-Aw32 was present in 26.9% of patients, but in only 0.8% of the controls (corrected P=0.000027). The possible importance of associations between antigens of the HLA-A locus with certain diseases are discussed. Family analyses and haplotype determinations proved to be unproductive because no familial clustering of ITP was found.

Key words

HLA antigensIdiopathic thrombocytopenic purpura
Download to read the full article text

Copyright information

© Springer-Verlag 1978