, Volume 27, Issue 2, pp 111-116

Possible anticholinesterase-like effects of trans(−)δ8 and -δ9tetrahydrocannabinol as observed in the general motor activity of mice

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The general motor activity of mice, measured by photobeam interruption, was depressed following dosage with trans(−)δ 8 and -δ 9tetrahydrocannabinol. The effect was similar to that obtained with synhexyl, pentobarbital, and eserine, but directly opposite to the stimulatory effect obtained with Ditran and scopolamine. The depressant effect of the tetrahydrocannabinols, synhexyl and eserine was potentiated by tacrine while the stimulant effect of Ditran and scopolamine was antagonized. Pentobarbital did not reveal any interaction with tacrine. Thus, the tetrahydrocannabinols appeared to possibly have an anticholinesterase sedative-like action. The compatibility of the finding with earlier reports suggesting anticholinergic-like actions of tetrahydrocannabinols and the drug-behavior interaction implications are discussed.

The research reported herein was supported by Grant No. 607-23-1 from the Canadian Department of National Health and Welfare. The tetrahydrocannabinol samples were generously supplied by Dr. A. B. Morrison, Deputy Director-General, Canadian Food and Drug Directorate.