Psychopharmacologia

, Volume 43, Issue 1, pp 31–36

Tolerance to the effects of Δ9-tetrahydrocannabinol in mice on intestinal motility, temperature and locomotor activity

  • Pamela F. Anderson
  • D. M. Jackson
  • G. B. Chesher
  • R. Malor
Animal Studies

DOI: 10.1007/BF00437611

Cite this article as:
Anderson, P.F., Jackson, D.M., Chesher, G.B. et al. Psychopharmacologia (1975) 43: 31. doi:10.1007/BF00437611

Abstract

The onset and duration of tolerance to three effects of δ9-tetrahydrocannabinol (δ9-THC) given orally to mice were compared. The effects of δ9-THC studied were: hypothermia, the depression of intestinal motility and the effect on spontaneous locomotor activity. When mice were dosed and tested at 24 hrs intervals it was apparent that tolerance was complete to its hypothermic and locomotor depressant effects after the first doses and to depression of intestinal motility after the fourth dose. Duration of tolerance also differed so that the normal hypothermic response had returned after 12 dose-free days, but not after 5 drug-free days; the effect on locomotor activity had returned within 4 days; and, apparent partial tolerance to the depressant effect of an acute challenging dose of δ9-THC on intestinal motility still existed after 19 dose-free days.

It is apparent that the time of onset and the duration of tolerance to δ9-THC in mice showed a different pattern in the three parameters studied. It seems unlikely therefore that any one mechanism, such as metabolic tolerance, explains all the results observed and that several mechanisms should be explored to explain the phenomenon of tolerance to δ9-THC.

Key words

δ9-TetrahydrocannabinolToleranceHypothermiaIntestinal MotilityLocomotor Activity

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Pamela F. Anderson
    • 1
  • D. M. Jackson
    • 1
  • G. B. Chesher
    • 1
  • R. Malor
    • 1
  1. 1.Department of PharmacologyUniversity of SydneyAustralia