Article

Mycopathologia

, Volume 84, Issue 2, pp 81-85

First online:

Strain differentiation of pathogenic yeasts by the killer system

  • G. MoraceAffiliated withIstituto di Microbiologia, Facoltà di Medicina e Chirurgia Agostino Gemelli, Università Cattolica del Sacro Cuore
  • , C. ArchibusacciAffiliated withIstituto di Microbiologia, Facoltà di Medicina e Chirurgia Agostino Gemelli, Università Cattolica del Sacro Cuore
  • , M. SestitoAffiliated withIstituto di Microbiologia, Facoltà di Medicina e Chirurgia Agostino Gemelli, Università Cattolica del Sacro Cuore
  • , L. PolonelliAffiliated withIstituto di Microbiologia, Facoltà di Medicina e Chirurgia Agostino Gemelli, Università Cattolica del Sacro Cuore

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Abstract

High sensitivity rates to the activity of killer toxins produced by 25 species of yeasts belonging to the genera Candida, Hansenula, Pichia, Rhodotorula, Saccharomyces and Trichosporon have been observed among 112 yeast isolates (25 Cryptococcus neoformans, 29 C. glabrata, 16 C. parapsilosis, 20 C. pseudotropicalis and 22 C. tropicalis). The highest sensitivity has been observed among the C. parapsilosis isolates, the lowest in C. glabrata strains. Genera Pichia and Hansenula proved to have the greatest killer activity. A killer system, formerly used for differentiating C. albicans isolates within the species, proved to be valid as epidemiological marker when applied to 112 strains of pathogenic yeasts.