, Volume 76, Issue 2, pp 157-159

6-(3-Chloro)-phenoxy-2-methyl-1-oxa-4-azospiro-[4,5]decane-3-one (CERM 3726) and sleep of healthy men

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Abstract

Immediate effects on sleep of 100, 200 and 300 mg 6-(3-chloro)-phenoxy-2-methyl-1-oxa-4-azospiro-[4,5]decane-3-one (CERM 3726) were studied in six healthy males. There was some sleep disturbance in two subjects with 100 and 200 mg, but only with 300 mg was there unequivocal evidence of reduced total sleep time and stage 2 sleep, together with a trend toward reduced rapid eye movement sleep. Arousal, at least as indicated by sleep studies, may be associated with the reported effect of the drug to oppose the deterioration in performance of tests of prolonged duration.